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Complications of hypertension : ウィキペディア英語版
Complications of hypertension

Complications of hypertension are clinical outcomes that result from persistent elevation of blood pressure. Hypertension is a risk factor for all clinical manifestations of atherosclerosis since it is a risk factor for atherosclerosis itself. It is an independent predisposing factor for heart failure, coronary artery disease, stroke,〔 renal disease, and peripheral arterial disease. It is the most important risk factor for cardiovascular morbidity and mortality, in industrialized countries.
== Complications affecting the heart ==

Hypertensive heart disease is the result of structural and functional adaptations leading to left ventricular hypertrophy, diastolic dysfunction,〔〔 CHF, abnormalities of blood flow due to atherosclerotic coronary artery disease〔 and microvascular disease,〔〔 and cardiac arrhythmias.〔 Individuals with left ventricular hypertrophy are at increased risk for, stroke, CHF,〔 and sudden death.〔 Aggressive control of hypertension can regress or reverse left ventricular hypertrophy and reduce the risk of cardiovascular disease.
left ventricular hypertrophy are seen in 25% of the hypertensive patients and can easily be diagnosed by using echocardiography. Underlying mechanisms of hypertensive left ventricular hypertrophy are of 2 types: mechanical, mainly leading to myocyte hypertrophy; neuro-hormonal, mainly resulting in a fibroblastic proliferation.〔
Abnormalities of diastolic function, ranging from asymptomatic heart disease to overt heart failure, are common in hypertensive patients. Patients with diastolic heart failure have a preserved ejection fraction, which is a measure of systolic function. Diastolic dysfunction is an early consequence of hypertension-related heart disease and is exacerbated by left ventricular hypertrophy〔〔 and ischemia.

抄文引用元・出典: フリー百科事典『 ウィキペディア(Wikipedia)
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